| S-CLASS Coupe CL 600 (215.378)Coupe | 1999 – 2006 | 5.8L | 367 hp (270 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 600, S 600 L (220.878, 220.178)Saloon | 2000 – 2005 | 5.8L | 367 hp (270 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS Coupe CL 55 AMG (215.373)Coupe | 1999 – 2006 | 5.4L M 113.986 | 360 hp (265 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS Coupe CL 63 AMG (216.374)Coupe | 2010 – 2013 | 5.5L | 571 hp (420 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 600, S 600 L (220.176)Saloon | 2002 – 2005 | 5.5L M 275.950 | 500 hp (368 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 65 AMG, S 65 AMG L (220.179)Saloon | 2004 – 2005 | 6.0L M 275.980 | 612 hp (450 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 350 (221.056, 221.156)Saloon | 2005 – 2013 | 3.5L M 272.965 | 272 hp (200 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 500 (221.071, 221.171)Saloon | 2005 – 2013 | 5.5L M 273.961 | 369 hp (271 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 320 CDI (221.022, 221.122)Saloon | 2005 – 2009 | 3.0L OM 642.930 | 211 hp (155 kW) | Diesel | Rear-Wheel Drive |
| S-CLASS S 450, S 450 L (221.070, 221.170)Saloon | 2005 – 2013 | 4.7L M 273.922 | 340 hp (250 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 600 (221.176)Saloon | 2005 – 2013 | 5.5L | 517 hp (380 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 65 AMG (221.179)Saloon | 2005 – 2013 | 6.0L M 275.982 | 612 hp (450 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS Coupe CL 500 (216.371)Coupe | 2006 – 2013 | 5.5L M 273.961 | 369 hp (271 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS Coupe CL 600 (216.376)Coupe | 2006 – 2013 | 5.5L M 275.953 | 517 hp (380 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 420 CDI (221.028, 221.128)Saloon | 2006 – 2009 | 4.0L OM 629.911 | 320 hp (235 kW) | Diesel | Rear-Wheel Drive |
| S-CLASS S 63 AMG (221.077, 221.177)Saloon | 2006 – 2013 | 6.2L M 156.984 | 525 hp (386 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS Coupe CL 63 AMG (216.377)Coupe | 2006 – 2013 | 6.2L M 156.984 | 525 hp (386 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS Coupe CL 65 AMG (216.379)Coupe | 2006 – 2010 | 6.0L | 612 hp (450 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 400 Hybrid (221.095, 221.195)Saloon | 2009 – 2013 | 3.5L M 272.974 | 272 hp (200 kW) | Petrol/Electric | Rear-Wheel Drive |
| S-CLASS S 280 (221.054)Saloon | 2006 – 2013 | 3.0L M 272.946 | 231 hp (170 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 300 (221.054, 221.154)Saloon | 2006 – 2013 | 3.0L M 272.946 | 231 hp (170 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 63 AMG (221.074, 221.174)Saloon | 2012 – 2013 | 5.5L | 571 hp (420 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS Coupe CL 500 (216.373)Coupe | 2011 – 2013 | 4.7L | 435 hp (320 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS Coupe CL 63 AMG (216.374)Coupe | 2011 – 2013 | 5.5L | 544 hp (400 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS Coupe CL 65 AMG (216.379)Coupe | 2011 – 2013 | 6.0L | 630 hp (463 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 350 BlueTec (221.026, 221.126)Saloon | 2011 – 2013 | 3.0L OM 642.862 | 258 hp (190 kW) | Diesel | Rear-Wheel Drive |
| S-CLASS S 350 CGI (221.057, 221.157)Saloon | 2011 – 2013 | 3.5L M 276.950 | 306 hp (225 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 500 CGI (221.073, 221.173)Saloon | 2011 – 2013 | 4.7L | 435 hp (320 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 63 AMG (221.074, 221.174)Saloon | 2011 – 2013 | 5.5L | 544 hp (400 kW) | Petrol | Rear-Wheel Drive |
| S-CLASS S 65 AMG (221.179)Saloon | 2010 – 2013 | 6.0L M 275.982 | 612 hp (450 kW) | Petrol | Rear-Wheel Drive |